Dysregulation of type I interferon responses in COVID-19
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چکیده
منابع مشابه
Hantavirus Regulation of Type I Interferon Responses
Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early interferon induction. PHV replication is blocked in human ECs, but not inhibited in IFN deficient VeroE6 cells and consistent with this, infecti...
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Scientists have been investigating the critical role type 1 interferons (IFN-I) play in controlling viral infections for more than 50 y. Common pathogen motifs present on viral particles trigger intracellular and membrane-associated pattern recognition receptors, leading to the production of IFN-I and rapid expression of interferon stimulated genes (ISIGs). ISIGs encode proteins with direct ant...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2020
ISSN: 1474-1733,1474-1741
DOI: 10.1038/s41577-020-0346-x